2015-7-2 · 王艳华,彭遥,夏连续.中国土拉弗朗西斯菌holarctica亚种的遗传多样性[J].中华流行病学杂志,2015,36(12):1410-1414 中国土拉弗朗西斯菌holarctica亚种的遗传多样性 Genetic diversity of Francisella tularensis subsp. holarctica in China 收稿日期:2015-07-02

Pathogenicity: F. tularensis has two main pathogenic serotypes: Subspecies tularenis (type-A) and subspecies holarctica (type-B). Both types possess a thin, antiphagocytic lipid capsule of high lipid concentration, and the lose of the capsule is associated with decreased virulence. Sep 05, 2018 · F tularensis biovar holarctica (also known as F tularensis biovar palearctica) is found primarily in Europe and Asia but has also been identified in cases of tularemia in North America. It is from this less-virulent subspecies that the live virus vaccine is derived. F tularensis biovars novicida and mediasiatica are of low F. tularensis subspecies tularensis (type A) is limited to North America; subspecies holarctica (type B) occurs in North America and Eurasia and typically causes milder symptoms than type A [1, 3]. Health care providers (HCPs) can be exposed to F. tularensis during routine patient care or when performing aerosol-generating procedures such as Apr 29, 2011 · To put into perspective how powerful a biological weapon F. tularensis can be, the WHO in 1969 estimated that "an aerosol dispersal of 50 kg of virulent F. tularensis over a metropolitan area with 5 million inhabitants in a developed country would result in 250,000 illnesses, including 19,000 deaths."(2) Current Research. 1. (F. tularensis subsp. tularensis, F. tularensis subsp. holarctica, and F. tularensis subsp. mediasiatica) have a duplicated Francisella pathogenicity island (FPI) and numerous insertionsequence(IS)elements.Incontrast,thegenomeofopportunisticF. tularensis subsp. novicida contains a single FPI and just a few IS elements but still causes Outbreaks of tularemia are caused by the bacterium Francisella tularensis holarctica throughout the Northern Hemisphere and by F. tularensis tularensis in North America only. Routes of infection include transmission from blood-sucking arthropods and through contact with infected dead or live animals, as well as from aerosols, dust, and water ( 1 ). Two main genetic groups (B.12 and B.FTNF002-00) of Francisella tularensis ssp. holarctica are endemic in Europe. The B.FTNF002-00 group proved to be dominant in Western European countries, while strains of the B.12 group were isolated mainly in Northern, Central and Eastern Europe. The clinical course of tularemia in the European brown hare (Lepus europaeus) also shows distinct patterns

Jun 03, 2020 · tularensis have been recognized (tularensis, holarctica, mediasiatica and novicida) which possess differential host ranges and cause disease with varying degrees of morbidity and mortality [2, 3]. While F. tularensis is capable of replicating in a variety of cell types, growth within macrophages is believed to be the primary mediator of disease

Phylogeography of Francisella tularensis subsp. holarctica Most F. tularensis subsp. holarctica isolates from Europe belong to these 2 geographically segregated groups. F rancisella tularensis is the etiologic agent of tularemia and a highly virulent category A biothreat agent (1,2). The most widely distributed subspecies is F. tularensis subsp. holarctica, which is found throughout much of the

(F. tularensis subsp. tularensis, F. tularensis subsp. holarctica, and F. tularensis subsp. mediasiatica) have a duplicated Francisella pathogenicity island (FPI) and numerous insertionsequence(IS)elements.Incontrast,thegenomeofopportunisticF. tularensis subsp. novicida contains a single FPI and just a few IS elements but still causes

(F. tularensis subsp. tularensis, F. tularensis subsp. holarctica, and F. tularensis subsp. mediasiatica) have a duplicated Francisella pathogenicity island (FPI) and numerous insertionsequence(IS)elements.Incontrast,thegenomeofopportunisticF. tularensis subsp. novicida contains a single FPI and just a few IS elements but still causes Outbreaks of tularemia are caused by the bacterium Francisella tularensis holarctica throughout the Northern Hemisphere and by F. tularensis tularensis in North America only. Routes of infection include transmission from blood-sucking arthropods and through contact with infected dead or live animals, as well as from aerosols, dust, and water ( 1 ). Two main genetic groups (B.12 and B.FTNF002-00) of Francisella tularensis ssp. holarctica are endemic in Europe. The B.FTNF002-00 group proved to be dominant in Western European countries, while strains of the B.12 group were isolated mainly in Northern, Central and Eastern Europe. The clinical course of tularemia in the European brown hare (Lepus europaeus) also shows distinct patterns